Lanostane-type triterpenes from the mushroom Astraeus pteridis with Antituberculosis Activity

Rita Stanikunaite; Mohamed Radwan; James M. Trappe; Frank Fronczek; Samir A. Ross

Treesearch

Lanostane-type triterpenes from the mushroom Astraeus pteridis with Antituberculosis Activity

Informally Refereed

Authors:

Rita Stanikunaite, Mohamed Radwan, James M. Trappe, Frank Fronczek, Samir A. Ross

Year:

2008

Type:

Scientific Journal

Station:

Pacific Northwest Research Station

Source:

Journal of Natural Products. 71: 2077-2079

Download (PDF 873 KB)

Download (PDF 873 KB): https://research.fs.usda.gov/download/treesearch/33307.pdf

Abstract

Bioassay-guided fractionation of an EtOH extract of the truffle-mimiking mushroom Astraeus pteridis led to the isolation and identification of three new (3-5) and two known (1, 2) lanostane triterpenes and phenylalanine betaine (6). The structures of the isolates were elucidated on the basis of 1D and 2D NMR spectroscopic data, HRESIMS results, and X-ray crystallographic analysis. Compounds 5 and 1 showed moderate activity against Mycobacterium tuberculosis with MIC values of 34.0 and 58.0 Î¼g/mL, respectively.

Keywords

Mushroom, Astraeus pteridis, lanostane triterpenes

Citation

Stanikunaite, Rita; Radwan, Mohamed; Trappe, James M.; Fronczek, Frank; Ross, Samir A. 2008. Lanostane-type triterpenes from the mushroom Astraeus pteridis with Antituberculosis Activity. Journal of Natural Products. 71: 2077-2079