Cyclooxygenase-2 inhibitory and antioxidant compounds from the truffle Elaphomyces granulatus

Rita Stanikunaite; Shabana I. Khan; James M. Trappe; Samir A. Ross

Treesearch

Cyclooxygenase-2 inhibitory and antioxidant compounds from the truffle Elaphomyces granulatus

Formally Refereed

Authors:

Rita Stanikunaite, Shabana I. Khan, James M. Trappe, Samir A. Ross

Year:

2009

Type:

Scientific Journal

Station:

Pacific Northwest Research Station

Source:

Phytotherapy Research. 23: 575-578

Download (PDF 1.07 MB)

Download (PDF 1.07 MB): https://research.fs.usda.gov/download/treesearch/37231.pdf

Abstract

The ethanol extract of fruiting bodies of Elaphomyces granulatus, a truffle-like fungus, was evaluated for cyclooxygenase-2 (COX-2) enzyme inhibitory and antioxidant activities. Inhibition of COX-2 activity was evaluated in mouse macrophages (RAW 264.7). The extract of E. granulatus caused a 68% inhibition of COX-2 activity at 50 ug/mL. Bioassay-guided investigation led to the isolation and identification of two active compounds, syringaldehyde and syringic acid.

Keywords

Elaphomyces granulatus, Ascomycota, hypogeous, truffle, COX-2, RAW 2647 cells, antiinflammatory, antioxidants, DCFH oxidation, HL-60 cells

Citation

Stanikunaite, Rita; Khan, Shabana I.; Trappe, James M.; Ross, Samir A. 2009. Cyclooxygenase-2 inhibitory and antioxidant compounds from the truffle Elaphomyces granulatus. Phytotherapy Research. 23: 575-578.