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Abstract
The utilization of stored lipids (fat) for energy metabolism appears to be a fundamental process for many biological systems especially during the early stages of their development. The participation of the glyoxylate cycle (GOG) together with other metabolic sequences like gluconeogenesis and beta oxidation are necessary for the conversion of lipids to carbohydrates. This report describes the distribution of the GOG amongst biological systems and examines its importance to the development and existence of biological cells under different physiological conditions. The report also describes some of our work which focuses on the role of the GOG in non-parasitic (
Caenorhabditis elegans) and parasitic (
Ascaris lumbricoides) nematodes. It was possible to demonstrate the
in vivo and
in vitro inhibition of isocitrate lyase (ICL), a key enzyme of the GOC operating in these nematodes by itaconate. Finally this report explores the possibility of using target specific inhibitor like itaconate to control spruce budworm (
Choristoneura fumiferana), populations.
Parent Publication
Citation
Patel, Thakor R. . 1983. Spruce Budworm and Energy Metabolism? In: Talerico, Robert L.; Montgomery, Michael, tech. coords. Proceedings, forest defoliator--host interactions: A comparison between gypsy moth and spruce budworms; 1983 April 5-7; New Haven, CT. Gen. Tech. Rep. NE-85. Broomall, PA: U.S. Department of Agriculture, Forest Service, Northeastern Forest Experiment Station: 25-31.
