Letter to the Editor Concerning “Simultaneous, Single-Particle Measurements of Size and Loading Give Insights into the Structure of Drug-Delivery Nanoparticles”

Abstract

The vexing error of excess variance in measurements of nanoparticle size distributions degrades accuracy in applications ranging from quality control of nanoparticle products to hazard assessment of nanoplastic byproducts. The particular importance of lipid nanoparticles for vaccine and medicine delivery motivates this Letter to the Editor, which concerns a publication 1 in ACS Nan and also presents original research. In ref 1, the benchmark measurements of a nanoparticle standard manifest large errors of the size distribution that contradict the claim of validation. In subsequent applications of the method to measure lipid nanoparticles, potential errors could bias the correlation of fuorescence intensity as a optical proxy for molecular loading and give misleading insights from power-law models of intensity−size trends. Looking forward, measurement error models may address this issue.

Citation

Madison, Andrew C.; Pintar, Adam L.; Copeland, Craig R.; Farkas, Natalia; Stavis, Samuel M. 2023. Letter to the Editor Concerning “Simultaneous, Single-Particle Measurements of Size and Loading Give Insights into the Structure of Drug-Delivery Nanoparticles”. ACS Nano. 17(10): 8837-8842. https://doi.org/10.1021/acsnano.2c04894.