Synthesis, X-ray structure, and hydrolytic chemistry of the high potent antiviral polyniobotungstate A-[alpha]-[Si2Nb6W18O77]8–

Gyu-Shik Kim; Huadong Zeng; Jeffrey T. Rhule; Ira A. Weinstock; Craig L. Hill

Treesearch

Synthesis, X-ray structure, and hydrolytic chemistry of the high potent antiviral polyniobotungstate A-[alpha]-[Si2Nb6W18O77]8–

Informally Refereed

Authors:

Gyu-Shik Kim, Huadong Zeng, Jeffrey T. Rhule, Ira A. Weinstock, Craig L. Hill

Year:

1999

Type:

Miscellaneous Publication

Station:

Forest Products Laboratory

Source:

Chemical communication. (1999): Pages 1651-1652

Download (PDF 127 KB)

Download (PDF 127 KB): https://research.fs.usda.gov/download/treesearch/8823.pdf

Abstract

Potently antiviral polyniobotungstates have been structurally characterized; the dimer A-[alpha]-[Si2Nb6W18O77]8– cleaves cleanly to the monomer A-[alpha]-[SiNb3W9O40]7– within 1 min in aqueous solution buffered at physiological (neutral) pH establishing that the monomer and not the dimer is pharmacologically relevant.

Keywords

Polyniobotungstate, synthesis, X-ray structure, hydrolytic chemistry, antiviral properties

Citation

Kim, Gyu-Shik; Zeng, Huadong; Rhule, Jeffrey T.; Weinstock, Ira A.; Hill, Craig L. 1999. Synthesis, X-ray structure, and hydrolytic chemistry of the high potent antiviral polyniobotungstate A-[alpha]-[Si2Nb6W18O77]8–. Chemical communication. (1999): Pages 1651-1652