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Abstract
DNA contains the coding information for the entire set of proteins produced by an organism. The specific combination of proteins synthesized varies with developmental, metabolic and environmental circumstances. This variation is generated by regulatory mechanisms that direct the production of messenger ribonucleic acid (mRNA) and subsequent translation of the nucleotide sequence into amino acid sequences, among other fundamental processes including post-translational modifications. A major step of gene expression regulation is the control of transcription initiation by RNA polymerase II. Control systems that modulate mRNA synthesis are based on the specific recognition and interaction of proteins with cognate sites on the DNA. The complex network of DNA protein and protein-protein interactions determines the degree of transcription of a specific sequence and defines particular expression patterns. Ultimately, the outcome of this net of interactions provides the finely-tuned response to internal clues and environmental signals (Matthews, 1992).
Citation
Lobos, Sergio; Polanco, Rubén; Tello, Mario; Cullen, Dan ; Seelenfreund, Daniela; Vicuña, Rafael. 2011. Understanding LiP promoters from Phanerochaete chrysosporium: A bioinformatic analysis. In: Xia, Xuhua, ed. Selected works in bioinformatics. Rijeka, Croatia: InTech. Chapter 4: 57-80. ISBN: 978-953-307-281-4.
